非胆固醇甾醇与冠心病危险因素及颈动脉内膜中层厚度的关系：芬兰年轻人心血管风险研究。

Relation of non-cholesterol sterols to coronary risk factors and carotid intima-media thickness: the Cardiovascular Risk in Young Finns Study.

机构信息

Department of Medicine, Division of Internal Medicine, University of Helsinki, Helsinki, Finland.

出版信息

Atherosclerosis. 2010 Apr;209(2):592-7. doi: 10.1016/j.atherosclerosis.2009.10.013. Epub 2009 Oct 20.

DOI:10.1016/j.atherosclerosis.2009.10.013

PMID:19963215

Abstract

OBJECTIVES

The aim of the present study was to evaluate the role of cholesterol metabolism in the development of atheromatous artery disease.

METHODS

Serum synthesis (cholesterol precursors) and absorption markers (cholestanol, campesterol, sitosterol, and avenasterol) were related to coronary risk factors and vascular structure in a population-based sample of 468 randomly selected 33-39-year-old men on their regular habitual diet. Carotid artery intima-media thickness (IMT) and serum lipids (including cholesterol) and sterols were measured in 2001, and the subjects were ranked to decreasing cholesterol synthesis depicted by serum cholestanol quartiles defined 21 years earlier in adolescence.

RESULTS

Serum cholesterol was correlated with absorption (e.g. serum campesterol, p<0.05), but not with synthesis, or with cholestanol quartiles. Cholesterol metabolism (synthesis/absorption markers) decreased linearly (about 50%) with the increasing cholestanol quartiles. IMT differed between the age groups, but not between cholestanol quartiles. Serum triglycerides, apoprotein B, and body mass index decreased, and non-HDL cholesterol/apoprotein B values increased between the cholestanol quartiles, whereas LDL cholesterol was unchanged. Cholesterol synthesis markers were related to blood pressure and serum triglycerides, and negatively to HDL cholesterol level in total population and in most of the cholestanol quartiles (p from 0.05 to 0.001).

CONCLUSIONS

Variables of metabolic syndrome accumulated in quartiles of high synthesis of cholesterol. Non-cholesterol sterols were related to many classic coronary risk factors, but virtually not to serum cholesterol or vascular structure.

摘要

目的

本研究旨在评估胆固醇代谢在动脉粥样硬化疾病发展中的作用。

方法

在一项基于人群的研究中，我们对 468 名 33-39 岁的男性进行了随机选择，这些人在其常规习惯性饮食中，血清合成（胆固醇前体）和吸收标志物（胆甾烷醇、菜油甾醇、谷甾醇和燕麦固醇）与冠状动脉危险因素和血管结构相关。在 2001 年，我们测量了颈动脉内膜中层厚度（IMT）和血清脂质（包括胆固醇）和甾醇，并根据 21 年前青春期时血清胆甾烷醇四分位数定义的胆固醇合成逐渐减少对受试者进行了排名。

结果

血清胆固醇与吸收（例如血清菜油甾醇，p<0.05）相关，但与合成或胆甾烷醇四分位数无关。胆固醇代谢（合成/吸收标志物）随着胆甾烷醇四分位数的增加而线性下降（约 50%）。IMT 在年龄组之间存在差异，但在胆甾烷醇四分位数之间没有差异。血清甘油三酯、载脂蛋白 B 和体重指数降低，而非高密度脂蛋白胆固醇/载脂蛋白 B 值在胆甾烷醇四分位数之间增加，而 LDL 胆固醇不变。胆固醇合成标志物与血压和血清甘油三酯相关，与总人群和大多数胆甾烷醇四分位数（p 从 0.05 到 0.001）中的高密度脂蛋白胆固醇水平呈负相关。