Morris H G, Rusnak S A, Barzens K
Clin Pharmacol Ther. 1977 Sep;22(3):352-7. doi: 10.1002/cpt1977223352.
Blood specimens for measurement of leukocyte cyclic adenosine monophosphate (AMP) were obtained at weekly intervals from asthmatic children who were participating in a double-blind, crossover study to compare the effects of two adrenergic agents and a placebo. When patients were treated with the placebo, the basal measurements and the cyclic AMP responses of leukocytes to in vitro stimulation with epinephrine (10(-4) M) were similar to those of normal subjects but within one week after initiation of treatment with an adrenergic bronchodilator, leukocyte cyclic AMP responses to adrenergic stimulation in vitro decreased and remained low during the remainder of the treatment period. Within one week after discontinuation of adrenergic therapy, leukocyte cyclic AMP responses returned to the control level. Our results indicate that the alterations in leukocyte cyclic AMP metabolism which have been observed previously in asthmatic patients may result from medications used for treatment of asthma.
参与一项双盲交叉研究以比较两种肾上腺素能药物和一种安慰剂效果的哮喘患儿，每周采集血样以测定白细胞环磷酸腺苷（AMP）。当患者接受安慰剂治疗时，白细胞的基础测量值以及白细胞对肾上腺素（10⁻⁴ M）体外刺激的环磷酸腺苷反应与正常受试者相似，但在用肾上腺素能支气管扩张剂开始治疗后一周内，白细胞对体外肾上腺素能刺激的环磷酸腺苷反应降低，并在治疗期的剩余时间内保持较低水平。在停用肾上腺素能治疗后一周内，白细胞环磷酸腺苷反应恢复到对照水平。我们的结果表明，先前在哮喘患者中观察到的白细胞环磷酸腺苷代谢改变可能是由用于治疗哮喘的药物引起的。
