Lipworth B J, Clark R A, Dhillon D P, McDevitt D G
Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, UK.
Eur J Clin Pharmacol. 1990;38(2):203-5. doi: 10.1007/BF00265986.
Tremor (Tr), chronotropic (HR) and metabolic (K, Glu) responses to cumulative doses of inhaled salbutamol (100 micrograms to 4000 micrograms) were compared in an age and sex matched group of 7 normal (N) and asthmatic (A) subjects. Comparison of regression lines between groups showed differences in HR and K. This was also reflected in attenuation of maximum responses in group A, for HR and K. These results show subsensitivity of chronotropic and hypokalaemic responses in patients with asthma, which may reflect tachyphylaxis from the effects of long term inhaled salbutamol therapy.
在7名年龄和性别匹配的正常（N）受试者和哮喘（A）受试者组成的小组中，比较了吸入不同累积剂量沙丁胺醇（100微克至4000微克）后的震颤（Tr）、变时性（心率，HR）和代谢（钾离子、谷氨酸，K、Glu）反应。组间回归线比较显示心率和钾离子存在差异。这也反映在A组心率和钾离子最大反应的减弱上。这些结果表明哮喘患者变时性和低钾血症反应存在亚敏感性，这可能反映了长期吸入沙丁胺醇治疗的快速耐受现象。
