Yen Ruoh-Fang, Ting Lai-Lei, Cheng Mei-Fang, Wu Yen-Wen, Tzen Kai-Yuan, Hong Ruey-Long
Department of Nuclear Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Head Neck. 2009 Jun;31(6):717-24. doi: 10.1002/hed.21026.
This study was designed to compare (201)Tl single photon emission computed tomography (SPECT)/CT with 18-fluoro-2-deoxyglucose ((18)F-FDG) PET/CT in diagnosing recurrent skull base nasopharyngeal carcinoma (NPC).
Twenty-seven patients were recruited. Both (201)Tl SPECT/CT and (18)F-FDG PET/CT for each patient were performed at least 4 months later after initial therapy.
The sensitivity and specificity for (201)Tl SPECT/CT were 66.7% and 100%, and those for (18)F-FDG PET/CT were 86.7% and 75.0%. Lesion/background ratios were obtained for the 10 lesions that were both SPECT and PET true positive. For the 8 patients with recurrences in nasopharyngeal regions, PET lesion/background ratios were all higher than SPECT lesion/background ratios. For the 2 patients with intracranial metastases, SPECT lesion/background ratios were higher than PET lesion/background ratios.
(201)Tl SPECT/CT is as effective as (18)F-FDG PET/CT in detecting recurrent NPC. For intracranial recurrence, (201)Tl SPECT, because of its high intracranial lesion/background ratio, is probably better than (18)F-FDG PET.
本研究旨在比较铊-201（²⁰¹Tl）单光子发射计算机断层扫描（SPECT）/CT与18-氟-2-脱氧葡萄糖（¹⁸F-FDG）PET/CT在诊断复发性颅底鼻咽癌（NPC）中的应用。
招募了27例患者。每位患者的²⁰¹Tl SPECT/CT和¹⁸F-FDG PET/CT均在初始治疗后至少4个月进行。
²⁰¹Tl SPECT/CT的敏感性和特异性分别为66.7%和100%，¹⁸F-FDG PET/CT的敏感性和特异性分别为86.7%和75.0%。对SPECT和PET均为真阳性的10个病灶计算病灶/本底比值。对于8例鼻咽部复发患者，PET病灶/本底比值均高于SPECT病灶/本底比值。对于2例颅内转移患者，SPECT病灶/本底比值高于PET病灶/本底比值。
²⁰¹Tl SPECT/CT在检测复发性NPC方面与¹⁸F-FDG PET/CT效果相当。对于颅内复发，²⁰¹Tl SPECT因其较高的颅内病灶/本底比值，可能优于¹⁸F-FDG PET。
