笼形二价配体对蛋白质亚结构域活性的差异调节。
Differential regulation of protein subdomain activity with caged bivalent ligands.
作者信息
Mayer Günter, Müller Jens, Mack Timo, Freitag Daniel F, Höver Thomas, Pötzsch Bernd, Heckel Alexander
机构信息
Life and Medical Sciences, Program Unit Chemical Biology and Medicinal Chemistry, University of Bonn c/o Kekulé Institute for Organic Chemistry and Biochemistry, Gerhard-Domagk-Strasse 1, Bonn, Germany.
出版信息
Chembiochem. 2009 Mar 2;10(4):654-7. doi: 10.1002/cbic.200800814.
Subtle change: Spatiotemporal modulation of individual protein subdomains with light as the trigger signal becomes possible by using bivalent aptamers and introducing photolabile "caging groups" to switch individual aptamer modules ON or OFF differentially. To the best of our knowledge, this is the first study to show that it is possible to modulate individual domain activity in aptamers, and thus also domain activity in proteins, with light.
细微变化
通过使用二价适体并引入光不稳定的“笼蔽基团”以不同方式打开或关闭单个适体模块，利用光作为触发信号对单个蛋白质亚结构域进行时空调节成为可能。据我们所知，这是第一项表明利用光调节适体中单个结构域活性以及蛋白质中结构域活性是可行的研究。
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