Barken Israel, Geller Jack, Rogosnitzky Moshe
Prostate Cancer Research and Education Foundation, 5520 Wellesley St., Suite 103 B, La Mesa, CA 91942-2015, USA.
Anticancer Res. 2008 Nov-Dec;28(6A):3701-4.
Noscapine, a non-toxic alkaloid and common constituent of cough medicine, stabilises tubulin. It inhibits the growth of several human and murine neoplasms, with no significant toxicity. Its effect on prostate cancer has not been evaluated.
Noscapine was administered orally (300 mg/kg per day) for 56 days to PC3 human prostate cancer-bearing immunodeficient mice (n=10). Immunodeficient control mice (n=10) received only diluent in an identical regimen.
Mean total tumour weight was 0.42 +/- 0.23 g and 0.97 +/- 0.31 g (p<0.001) in the noscapine-treated group and the control group, respectively, without evidence of toxicity. Metastases occurred less frequently in the treatment than the control group (30% vs. 90%; p<0.05).
Oral administration of noscapine limited tumour growth and lymphatic metastasis of PC3 human prostate cancer in this mouse model, supporting its therapeutic potential as a nontoxic and easily administered treatment for metastatic cancer.
那可丁是一种无毒生物碱，也是止咳药的常见成分，可使微管蛋白稳定。它能抑制多种人类和小鼠肿瘤的生长，且无明显毒性。其对前列腺癌的作用尚未得到评估。
对10只荷人PC3前列腺癌的免疫缺陷小鼠口服给予那可丁（每天300mg/kg），持续56天。10只免疫缺陷对照小鼠在相同方案下仅接受稀释剂。
那可丁治疗组和对照组的平均肿瘤总重量分别为0.42±0.23g和0.97±0.31g（p<0.001），且无毒性迹象。治疗组发生转移的频率低于对照组（30%对90%；p<0.05）。
在该小鼠模型中，口服那可丁可限制人PC3前列腺癌的肿瘤生长和淋巴转移，支持其作为转移性癌症无毒且易于给药的治疗方法的治疗潜力。
