Intramembrane-cleaving proteases.
作者信息
Wolfe Michael S
机构信息
Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
出版信息
J Biol Chem. 2009 May 22;284(21):13969-73. doi: 10.1074/jbc.R800039200. Epub 2009 Feb 3.
Abstract
摘要
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本文引用的文献
1
Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases.信号肽肽酶介导的膜内蛋白水解作用：GXGD型天冬氨酸蛋白酶的比较探讨
J Biol Chem. 2009 May 22;284(21):13975-9. doi: 10.1074/jbc.R800040200. Epub 2009 Feb 3.
2
The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.早老素1的C末端PAL基序和跨膜结构域9参与γ-分泌酶催化孔的形成。
J Neurosci. 2008 Jun 11;28(24):6264-71. doi: 10.1523/JNEUROSCI.1163-08.2008.
3
Direct and potent regulation of gamma-secretase by its lipid microenvironment.γ-分泌酶受其脂质微环境的直接且强效调控。
J Biol Chem. 2008 Aug 15;283(33):22529-40. doi: 10.1074/jbc.M801925200. Epub 2008 Jun 6.
4
Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity.尼卡斯特林胞外结构域中的Glu(332)对γ-分泌酶复合物成熟至关重要，但对其活性并非如此。
J Biol Chem. 2008 Jul 18;283(29):20096-105. doi: 10.1074/jbc.M803040200. Epub 2008 May 23.
5
Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase.早老素的跨膜结构域9决定了γ-分泌酶催化位点的动态构象。
J Biol Chem. 2008 Jul 11;283(28):19793-803. doi: 10.1074/jbc.M802461200. Epub 2008 May 15.
6
Substrate specificity of gamma-secretase and other intramembrane proteases.γ-分泌酶及其他膜内蛋白酶的底物特异性
Cell Mol Life Sci. 2008 May;65(9):1311-34. doi: 10.1007/s00018-008-7462-2.
7
Structure of a site-2 protease family intramembrane metalloprotease.2型位点蛋白酶家族跨膜金属蛋白酶的结构
Science. 2007 Dec 7;318(5856):1608-12. doi: 10.1126/science.1150755.
8
Active gamma-secretase complexes contain only one of each component.活性γ-分泌酶复合物的每个组分仅含有一个。
J Biol Chem. 2007 Nov 23;282(47):33985-93. doi: 10.1074/jbc.M705248200. Epub 2007 Oct 2.
9
Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate.一种菱形膜内蛋白酶的酶学分析表明，跨膜螺旋5是侧向底物通道。
Proc Natl Acad Sci U S A. 2007 May 15;104(20):8257-62. doi: 10.1073/pnas.0700814104. Epub 2007 Apr 26.
10
Open-cap conformation of intramembrane protease GlpG.膜内蛋白酶GlpG的开放帽构象
Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2098-102. doi: 10.1073/pnas.0611080104. Epub 2007 Feb 2.
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