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Intramembrane-cleaving proteases.

作者信息

Wolfe Michael S

机构信息

Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

出版信息

J Biol Chem. 2009 May 22;284(21):13969-73. doi: 10.1074/jbc.R800039200. Epub 2009 Feb 3.

Abstract
摘要

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Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity.
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Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase.
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Structure of a site-2 protease family intramembrane metalloprotease.
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Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate.
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