Paulino Gabriel, Barbier de la Serre Claire, Knotts Trina A, Oort Pieter J, Newman John W, Adams Sean H, Raybould Helen E
Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, 1321 Haring Hall, Vet Med: APC, University of California, Davis, 1 Shields Ave., Davis, CA 95616, USA.
Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E898-903. doi: 10.1152/ajpendo.90796.2008. Epub 2009 Feb 3.
The vagal afferent pathway is important in short-term regulation of food intake, and decreased activation of this neural pathway with long-term ingestion of a high-fat diet may contribute to hyperphagic weight gain. We tested the hypothesis that expression of genes encoding receptors for orexigenic factors in vagal afferent neurons are increased by long-term ingestion of a high-fat diet, thus supporting orexigenic signals from the gut. Obesity-prone (DIO-P) rats fed a high-fat diet showed increased body weight and hyperleptinemia compared with low-fat diet-fed controls and high-fat diet-induced obesity-resistant (DIO-R) rats. Expression of the type I cannabinoid receptor and growth hormone secretagogue receptor 1a in the nodose ganglia was increased in DIO-P compared with low-fat diet-fed controls or DIO-R rats. Shifts in the balance between orexigenic and anorexigenic signals within the vagal afferent pathway may influence food intake and body weight gain induced by high fat diets.
迷走神经传入通路在食物摄入的短期调节中很重要，长期摄入高脂饮食导致该神经通路的激活减少可能会导致食欲亢进性体重增加。我们检验了这样一个假设，即长期摄入高脂饮食会增加迷走神经传入神经元中促食欲因子受体编码基因的表达，从而支持来自肠道的促食欲信号。与低脂饮食喂养的对照组和高脂饮食诱导的肥胖抵抗（DIO-R）大鼠相比，喂食高脂饮食的肥胖易感（DIO-P）大鼠体重增加且出现高瘦素血症。与低脂饮食喂养的对照组或DIO-R大鼠相比，DIO-P大鼠结节神经节中I型大麻素受体和生长激素促分泌素受体1a的表达增加。迷走神经传入通路中促食欲和抑食欲信号之间平衡的改变可能会影响高脂饮食诱导的食物摄入和体重增加。
