人血小板中的质膜氧化还原系统在血小板功能及血小板与白细胞相互作用中发挥作用。

The plasma membrane redox system in human platelet functions and platelet-leukocyte interactions.

作者信息

Del Principe Domenico, Frega Gianluca, Savini Isabella, Catani M Valeria, Rossi Antonello, Avigliano Luciana

机构信息

Department of Health and Cell Biology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

出版信息

Thromb Haemost. 2009 Feb;101(2):284-9.

PMID:19190811

Abstract

The plasma membrane electron transport is crucial for blood coagulation and thrombosis, since reactive oxygen species and thiol changes, generated by plasma membrane redox reactions, modulate activation of platelets, as well as their interaction with leukocytes. Several antioxidants are linked to this system; thus, platelets are also able to counterbalance radical production and to regulate thrombus growth. Aim of this review is to give an update on the plasma membrane redox system in platelets, as well as on its role in platelet functions and leukocyte-platelet cross-talk.

摘要

质膜电子传递对于血液凝固和血栓形成至关重要，因为质膜氧化还原反应产生的活性氧和硫醇变化可调节血小板的激活及其与白细胞的相互作用。几种抗氧化剂与该系统相关联；因此，血小板也能够平衡自由基的产生并调节血栓生长。本综述的目的是更新血小板质膜氧化还原系统及其在血小板功能和白细胞 - 血小板相互作用中的作用。