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[2000 - 2006年荷兰围产期死亡率;风险因素与风险选择]

[Perinatal mortality in The Netherlands 2000-2006; risk factors and risk selection].

作者信息

Ravelli A C J, Eskes M, Tromp M, van Huis A M, Steegers E A P, Tamminga P, Bonsel G J

机构信息

Afd. Klinische Informatiekunde, Academisch Medisch Centrum/Universiteit van Amsterdam, Postbus 22.660, 1100 DD Amsterdam.

出版信息

Ned Tijdschr Geneeskd. 2008 Dec 13;152(50):2728-33.

Abstract

OBJECTIVE

To gain insight in recent perinatal mortality figures in The Netherlands and their relation with important risk factors, risk groups and risk selection among pregnant women.

DESIGN

Retrospective cohort study.

METHOD

The National Obstetrical Registrations and the National Neonatal Registration were linked into The Netherlands Perinatal Registry to prevent double counting. From this database, data on 1.3 million births in the years 2000-2006 were analysed with perinatal mortality as outcome measure.

RESULTS

In 2006, perinatal mortality was 9.8 per 1000 total births (foetal mortality 6.8 per 1000 births and early neonatal mortality 3.1 per 1000 live births). Maternal age (< 20 and > or = 40 years) and high multiparity (> or = 4) were risk factors for perinatal mortality but showed low prevalence (< 3%). Non-Western ethnicity and nulliparity were important risk factors (relative risk of both 1.4) with a prevalence of 16% and 46%, respectively. The very preterm births (22.0-25.6 weeks of gestation) provided 29% ofall perinatal mortality with a mortality risk of 935 per 1000 births. Full-term births (> or = 37.0 weeks) accounted for 26% of all perinatal mortality with a mortality risk of 2.8 per 1000 births. In the full-term born group, perinatal mortality was 0.4 per 1000 births in home births, 2.7 per 1000 births in outpatient clinics and 4.5 per 1000 births when the women were referred to the gynaecologist before start of labour.

CONCLUSION

At a population level, low or high maternal age and high parity are less important risk factors than expected. More detailed research is indicated into the mortality ofvery preterm births but also offull-term born children.

摘要

目的

深入了解荷兰近期的围产期死亡率数据及其与重要风险因素、风险群体以及孕妇风险选择之间的关系。

设计

回顾性队列研究。

方法

将国家产科登记数据和国家新生儿登记数据链接到荷兰围产期登记处,以防止重复计数。从该数据库中,分析了2000 - 2006年期间130万例分娩的数据,以围产期死亡率作为结局指标。

结果

2006年,围产期死亡率为每1000例总出生数9.8例(胎儿死亡率为每1000例出生6.8例,早期新生儿死亡率为每1000例活产3.1例)。产妇年龄(<20岁和≥40岁)及高胎次(≥4次)是围产期死亡的风险因素,但发生率较低(<3%)。非西方族裔和初产是重要的风险因素(相对风险均为1.4),发生率分别为16%和46%。极早产(妊娠22.0 - 25.6周)占所有围产期死亡的29%,死亡风险为每1000例出生935例。足月产(≥37.0周)占所有围产期死亡的26%,死亡风险为每1000例出生2.8例。在足月产组中,在家分娩的围产期死亡率为每1000例出生0.4例,门诊分娩为每1000例出生2.7例,分娩前转诊至妇科医生的产妇所生婴儿的围产期死亡率为每1000例出生4.5例。

结论

在人群层面,产妇年龄过低或过高以及高胎次作为风险因素的重要性低于预期。需要对极早产以及足月产儿的死亡率进行更详细的研究。

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