比较未改性商业防晒霜中金属氧化物纳米颗粒的检测和表征方法。
Comparing methods for detecting and characterizing metal oxide nanoparticles in unmodified commercial sunscreens.
作者信息
Tyner Katherine M, Wokovich Anna M, Doub William H, Buhse Lucinda F, Sung Li-Piin, Watson Stephanie S, Sadrieh Nakissa
机构信息
Center for Drug Evaluation & Research, FDA, Silver Spring, MD 20993, USA.
出版信息
Nanomedicine (Lond). 2009 Feb;4(2):145-59. doi: 10.2217/17435889.4.2.145.
AIMS
To determine if commercial sunscreens contain distinct nanoparticles and to evaluate analytical methods for their ability to detect and characterize nanoparticles in unmodified topical products using commercial sunscreens as a model.
METHODS
A total of 20 methods were evaluated for their ability to detect and characterize nanoparticles in unmodified commercial sunscreens.
RESULTS
Variable-pressure scanning-electron microscopy, atomic-force microscopy, laser-scanning confocal microscopy and X-ray diffraction were found to be viable and complementary methods for detecting and characterizing nanoparticles in sunscreens.
CONCLUSIONS
It was determined that several of the commercial sunscreens contained distinct nanoparticles. No one method was able to completely characterize nanoparticles in the unmodified products but the viable methods provided complementary information regarding the nanoparticles and how they were interacting with the sunscreen matrix.
目的
确定市售防晒霜中是否含有独特的纳米颗粒，并以市售防晒霜为模型，评估分析方法检测和表征未改性局部用产品中纳米颗粒的能力。
方法
对总共20种方法检测和表征未改性市售防晒霜中纳米颗粒的能力进行了评估。
结果
发现可变压力扫描电子显微镜、原子力显微镜、激光扫描共聚焦显微镜和X射线衍射是检测和表征防晒霜中纳米颗粒的可行且互补的方法。
结论
已确定几种市售防晒霜含有独特的纳米颗粒。没有一种方法能够完全表征未改性产品中的纳米颗粒，但可行的方法提供了有关纳米颗粒及其与防晒基质相互作用方式的互补信息。
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