基于硼硅氧烷和氧化锌纳米颗粒的新型有机硅复合材料可抑制细菌生长，但对动物真核细胞的发育没有毒性作用。
New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells.
作者信息
Chausov Denis N, Burmistrov Dmitriy E, Kurilov Alexander D, Bunkin Nikolai F, Astashev Maxim E, Simakin Alexander V, Vedunova Maria V, Gudkov Sergey V
机构信息
Prokhorov General Physics Institute of the Russian Academy of Sciences, Vavilova St. 38, 119991 Moscow, Russia.
Bauman Moscow State Technical University, Vtoraya Baumanskaya ul. 5, 105005 Moscow, Russia.
出版信息
Materials (Basel). 2021 Oct 21;14(21):6281. doi: 10.3390/ma14216281.
The present study a comprehensive analysis of the antibacterial properties of a composite material based on borosiloxane and zinc oxide nanoparticles (ZnO NPs). The effect of the polymer matrix and ZnO NPs on the generation of reactive oxygen species, hydroxyl radicals, and long-lived oxidized forms of biomolecules has been studied. All variants of the composites significantly inhibited the division of bacteria and caused them to detach from the substrate. It was revealed that the surfaces of a composite material based on borosiloxane and ZnO NPs do not inhibit the growth and division of mammalians cells. It is shown in the work that the positive effect of the incorporation of ZnO NPs into borosiloxane can reach 100% or more, provided that the viscoelastic properties of borosiloxane with nanoparticles are retained.
本研究对基于硼硅氧烷和氧化锌纳米颗粒（ZnO NPs）的复合材料的抗菌性能进行了全面分析。研究了聚合物基体和ZnO NPs对活性氧、羟基自由基以及生物分子长寿命氧化形式生成的影响。复合材料的所有变体均显著抑制细菌分裂，并使其从底物上脱离。结果表明，基于硼硅氧烷和ZnO NPs的复合材料表面不会抑制哺乳动物细胞的生长和分裂。该研究表明，只要保留含纳米颗粒硼硅氧烷的粘弹性，将ZnO NPs掺入硼硅氧烷的积极效果可达100%或更高。
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