Kim Dal Y, Guzman Hilda, Bueno Rudy, Dennett James A, Auguste Albert J, Carrington Christine V F, Popov Vsevolod L, Weaver Scott C, Beasley David W C, Tesh Robert B
Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0609, USA.
Virology. 2009 Mar 30;386(1):154-9. doi: 10.1016/j.virol.2008.12.034. Epub 2009 Feb 3.
Recent reports indicate that flaviviruses similar to the cell fusing agent virus (CFAV) naturally infect a wide variety of mosquito species. These newly recognized insect-specific viruses comprise a distinct CFAV complex within the genus Flavivirus. Here, we describe the isolation and characterization of nine strains of Culex flavivirus (Cx FV), a member of the CFAV complex, from mosquitoes collected in the United States (East Texas) and Trinidad. Phylogenetic analyses of the envelope protein gene sequences of these nine mosquito isolates with those of other CFAV complex flaviviruses in GenBank indicate that the U.S. isolates group with CxFV isolates from Asia (Japan and Indonesia), while the Trinidad isolates are more similar to CxFV isolates from Central America. A discussion follows on the possible biological significance of the CFAV complex flaviviruses.
最近的报告表明，与细胞融合剂病毒（CFAV）相似的黄病毒可自然感染多种蚊虫。这些新发现的昆虫特异性病毒在黄病毒属内构成了一个独特的CFAV复合体。在此，我们描述了从美国（东得克萨斯州）和特立尼达采集的蚊虫中分离出的9株库蚊黄病毒（Cx FV）（CFAV复合体的一个成员）及其特性。对这9株蚊虫分离株的包膜蛋白基因序列与GenBank中其他CFAV复合体黄病毒的序列进行系统发育分析表明，美国的分离株与来自亚洲（日本和印度尼西亚）的CxFV分离株归为一组，而特立尼达的分离株与来自中美洲的CxFV分离株更为相似。随后讨论了CFAV复合体黄病毒可能的生物学意义。
