N'guyen Y, Andreoletti L, Patey M, Lecoq-Lafon C, Cornillet P, Léon A, Jaussaud R, Fieschi C, Strady C
Service de Médicine Interne et des Maladies Infectieuses, Hôpital Robert Debré-CHU Reims, Reims, France.
J Clin Microbiol. 2009 Apr;47(4):1252-4. doi: 10.1128/JCM.02052-08. Epub 2009 Feb 4.
We report a case of Epstein-Barr virus (EBV) primo infection with the development of successive infectious mononucleosis, hemophagocytic lymphohistiocytosis, and B-cell lymphoproliferative disorder in a patient treated with azathioprine for Crohn's disease. This case report suggests that specific EBV-related clinical and virological management should be considered when treating a patient with inflammatory bowel disease with azathioprine.
我们报告一例爱泼斯坦-巴尔病毒(EBV)原发性感染病例,该患者因克罗恩病接受硫唑嘌呤治疗,随后发展为传染性单核细胞增多症、噬血细胞性淋巴组织细胞增生症和B细胞淋巴增殖性疾病。本病例报告提示,在用硫唑嘌呤治疗炎症性肠病患者时,应考虑特定的EBV相关临床和病毒学管理。