Mohile Nimish A, Deangelis Lisa M, Abrey Lauren E
Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Clin Adv Hematol Oncol. 2008 Nov;6(11):818-20, 840.
18Fluoro-deoxyglucose positron emission tomography (FDG-PET) imaging has been widely incorporated into the management of systemic non-Hodgkin lymphoma. However, its utility in primary central nervous system lymphoma (PCNSL) is unclear. We report 28 PCNSL patients who underwent brain FDG-PET to inform clinical management. Baseline PET imaging demonstrated hypermetabolism consistent with aggressive lymphoma in 75% (9/12) of patients. FDG-PET used for response assessment or the interpretation of nonspecific magnetic resonance imaging abnormalities showed hypermetabolism in 50% (10/20) of patients, which was important in guiding further management. This data suggests that FDG-PET imaging in PCNSL is useful and may have a role in response assessment.
18氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）成像已广泛应用于系统性非霍奇金淋巴瘤的管理。然而，其在原发性中枢神经系统淋巴瘤（PCNSL）中的作用尚不清楚。我们报告了28例接受脑部FDG-PET检查以指导临床管理的PCNSL患者。基线PET成像显示，75%（9/12）的患者存在与侵袭性淋巴瘤一致的高代谢。用于疗效评估或解释非特异性磁共振成像异常的FDG-PET显示，50%（10/20）的患者存在高代谢，这对指导进一步治疗很重要。该数据表明，PCNSL中的FDG-PET成像很有用，可能在疗效评估中发挥作用。
