苯并三唑辅助亮氨酸脑啡肽、淀粉样β 片段 34-42 和其他“困难”肽序列的固相组装。
Benzotriazole-assisted solid-phase assembly of Leu-enkephalin, amyloid beta segment 34-42, and other "difficult" peptide sequences.
机构信息
Center for Heterocyclic Compounds and Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA.
出版信息
J Org Chem. 2009 Mar 6;74(5):2028-32. doi: 10.1021/jo8026214.
Microwave-assisted solid-phase syntheses of six "difficult" peptides, H-VVSVV-NH(2) (3), H-VVVSVV-NH(2) (4), H-VIVIG-OH (5), H-TVTVTV-NH(2) (6), H-VKDGYI-NH(2) (7), and H-VKDVYI-NH(2) (8), were achieved utilizing N-(Fmoc-alpha-aminoacyl)benzotriazoles. Extension to the syntheses of Leu-enkephalin (9) and amyloid-beta (34-42) (10) demonstrates that this strategy comprises an efficient route to new and known "difficult" peptides.
利用 N-(Fmoc-α-氨基酰基)苯并三唑，实现了六个“困难”肽 H-VVSVV-NH(2)（3）、H-VVVSVV-NH(2)（4）、H-VIVIG-OH（5）、H-TVTVTV-NH(2)（6）、H-VKDGYI-NH(2)（7）和 H-VKDVYI-NH(2)（8）的微波辅助固相合成。Leu-脑啡肽（9）和淀粉样β（34-42）（10）的合成延伸证明，该策略构成了新的和已知“困难”肽的有效途径。
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