Poccia Dominic, Larijani Banafshé
Department of Biology, Amherst College, Amherst, MA 01002, USA.
Biochem J. 2009 Mar 1;418(2):233-46. doi: 10.1042/BJ20082105.
Membrane fusion underlies many cellular events, including secretion, exocytosis, endocytosis, organelle reconstitution, transport from endoplasmic reticulum to Golgi and nuclear envelope formation. A large number of investigations into membrane fusion indicate various roles for individual members of the phosphoinositide class of membrane lipids. We first review the phosphoinositides as membrane recognition sites and their regulatory functions in membrane fusion. We then consider how modulation of phosphoinositides and their products may affect the structure and dynamics of natural membranes facilitating fusion. These diverse roles underscore the importance of these phospholipids in the fusion of biological membranes.
膜融合是许多细胞活动的基础，包括分泌、胞吐作用、胞吞作用、细胞器重构、从内质网到高尔基体的运输以及核膜形成。对膜融合的大量研究表明，膜脂磷酸肌醇类的各个成员具有多种作用。我们首先综述磷酸肌醇作为膜识别位点及其在膜融合中的调节功能。然后我们思考磷酸肌醇及其产物的调节如何影响促进融合的天然膜的结构和动力学。这些不同的作用强调了这些磷脂在生物膜融合中的重要性。
