Departments of Dermatology, Gazi University Faculty of Medicine, Ankara, Turkey.
Clin Exp Dermatol. 2010 Jan;35(1):47-50. doi: 10.1111/j.1365-2230.2008.03069.x. Epub 2009 Dec 13.
Keratosis lichenoides chronica (KLC) is a rare disease, with approximately 70 cases reported in the literature. The problem in this long-lasting disease is generally the treatment, not the diagnosis. In the literature, many treatments failed to show any beneficial effect. We present a 20-year-old man with KLC that was successfully treated with a combination of phototherapy, acitretin and calcipotriol ointment. The patient's lesions showed a marked improvement with this combination. To our knowledge, this is the first report of this type of combination treatment being used successfully in KLC. This approach might help reduce doses of retinoids or psoralen ultraviolet A required when these are used separately, and limit the potential toxicity of these treatments.
慢性线状苔癣样角化病（Keratosis lichenoides chronica，KLC）是一种罕见疾病，文献中约有 70 例报告。在这种长期存在的疾病中，问题通常在于治疗，而不是诊断。在文献中，许多治疗方法都未能显示出任何有益的效果。我们报告了一例 20 岁男性慢性线状苔癣样角化病，该患者接受光疗、阿维 A 酯和卡泊三醇软膏联合治疗后获得成功。该联合治疗使患者的皮损明显改善。据我们所知，这是首例成功应用该联合疗法治疗慢性线状苔癣样角化病的报告。这种方法可能有助于减少单独使用维 A 酸类或补骨脂素 UVA 时所需的剂量，并限制这些治疗方法的潜在毒性。
