Johansson Ann-Katrin, Johansson Anders, Unell Lennart, Ekbäck Gunnar, Ordell Sven, Carlsson Gunnar E
Department of Clinical Dentistry-Cariology, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Eur J Oral Sci. 2009 Feb;117(1):13-9. doi: 10.1111/j.1600-0722.2008.00597.x.
The aim of this study was to determine the changes in prevalence of xerostomia in subjects from 50 to 65 yr of age. Questionnaires were sent to all subjects who were born in 1942 and were living in two Swedish counties in 1992, 1997, 2002, and 2007. The analyses focused on those who answered the questionnaires both in 1992 and in 2007. The response rate was 71.4% (n = 6,346) in 1992 and 73.1% (n = 6,078) in 2007. Of those who answered the questionnaire in 1992, 74.3% (n = 4,714) also responded in 2007. There was an almost linear increase in the prevalence of xerostomia at the four study time-points (i.e. when the subjects were 50, 55, 60, and 65 yr of age). Xerostomia was more prevalent at night than during the day. The pooled prevalence of night-time and daytime xerostomia was 6% at 50 yr of age and 15% at 65 yr of age, and it was higher in women than in men on both occasions. Logistic regression analyses showed that impaired health and smoking were significantly associated with daytime xerostomia but not with night-time xerostomia. Despite the increase in prevalence of xerostomia from 50 to 65 yr of age, there was considerable variation during the observation period. The incidence rate was 13% (507/4,015) and the disappearance rate was 42% (104/250) (dichotomized answers).
本研究的目的是确定50至65岁受试者中口干症患病率的变化。向所有1942年出生且在1992年、1997年、2002年和2007年居住在瑞典两个县的受试者发放问卷。分析集中在那些在1992年和2007年都回答了问卷的人。1992年的回复率为71.4%（n = 6346），2007年为73.1%（n = 6078）。在1992年回答问卷的人中，74.3%（n = 4714）在2007年也做出了回复。在四个研究时间点（即受试者50岁、55岁、60岁和65岁时），口干症的患病率几乎呈线性增加。口干症在夜间比白天更普遍。50岁时夜间和白天口干症的合并患病率为6%，65岁时为15%，且在这两种情况下女性患病率均高于男性。逻辑回归分析表明，健康受损和吸烟与白天口干症显著相关，但与夜间口干症无关。尽管50至65岁口干症患病率有所增加，但在观察期内仍存在相当大的差异。发病率为13%（507/4015），消失率为42%（104/250）（二分法答案）。
