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挪威奥斯陆 65 岁人群中的口干症和唾液分泌减少。

Xerostomia and hyposalivation among a 65-yr-old population living in Oslo, Norway.

机构信息

Department of Cariology and Gerodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway.

Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway.

出版信息

Eur J Oral Sci. 2021 Feb;129(1):e12757. doi: 10.1111/eos.12757. Epub 2021 Jan 27.

Abstract

This study aimed to describe the prevalence and associated factors for xerostomia and hyposalivation in a young-elderly population. A random sample of 460 65-yr-old people living in Oslo, Norway, answered a questionnaire and underwent a clinical examination (237 men and 223 women; response rate 58%). Ten percent of respondents reported xerostomia. The median Summated Xerostomia Index was 6 (interquartile range [IQR]: 5-7) and the median Clinical Oral Dryness Score was 2 (IQR: 1-3). The median unstimulated whole saliva (UWS) secretion rate was 0.34 (IQR: 0.20-0.53) mL min and the median stimulated whole saliva (SWS) secretion rate was 1.74 (IQR: 1.24-2.38) mL min . In 8% of the study participants the UWS secretion rate was ≤0.1 mL min and in 4% the SWS secretion rate was ≤0.7 mL min . Three percent of the study participants had both xerostomia and hyposalivation with respect to UWS. Xerostomia was significantly associated with medication use, having rheumatic disease, and having received radiation therapy to the head/neck region. Hyposalivation with respect to UWS and SWS was significantly associated with medication use and type II diabetes. Even though xerostomia and hyposalivation were not prevalent conditions in this population, clinicians should be especially aware of the salivary conditions in patients taking four or more medications, patients diagnosed with type II diabetes, and those who have undergone radiation therapy to the head/neck region.

摘要

本研究旨在描述年轻老年人中口干和唾液分泌减少的患病率及其相关因素。在挪威奥斯陆,一个随机抽取的 460 名 65 岁人群回答了一份问卷并接受了临床检查(男性 237 名,女性 223 名;应答率 58%)。10%的受访者报告有口干。汇总的口干指数中位数为 6(四分位距[IQR]:5-7),临床口腔干燥评分中位数为 2(IQR:1-3)。未刺激全唾液(UWS)分泌率中位数为 0.34(IQR:0.20-0.53)ml/min,刺激全唾液(SWS)分泌率中位数为 1.74(IQR:1.24-2.38)ml/min。在 8%的研究参与者中,UWS 分泌率≤0.1ml/min,在 4%的参与者中,SWS 分泌率≤0.7ml/min。3%的研究参与者有口干和 UWS 唾液分泌减少的情况。口干与用药、风湿性疾病和头颈部放疗显著相关。UWS 和 SWS 唾液分泌减少与用药和 2 型糖尿病显著相关。尽管在该人群中口干和唾液分泌减少的情况并不普遍,但临床医生应特别注意服用四种或更多药物、诊断为 2 型糖尿病以及头颈部接受放疗的患者的唾液状况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ef5/7986810/500fb5f71b1d/EOS-129-0-g002.jpg

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