Esposito S, Thadepalli H, Benler H A, Chuah S K
Department of Infectious Diseases, University of Naples, Italy.
J Chemother. 1991 Jun;3(3):147-51. doi: 10.1080/1120009x.1991.11739082.
Pseudomonas keratitis is difficult to treat and aminoglycosides, the drugs now used for this purpose, are not always effective. New drugs are thus needed to cure gentamicin resistant pseudomonas ocular infections. Enoxacin, a new quinolone, active in vitro against Pseudomonas aeruginosa, was evaluated in experimental ulcerative keratitis produced by a gentamicin resistant isolate of Pseudomonas aeruginosa in rabbits. Our study shows that enoxacin eye drops eliminated pseudomonas infection of the cornea and achieved therapeutic levels in the aqueous humor. Supplementation with parenterally given enoxacin augmented this effect. Enoxacin did not penetrate the vitreous. Enoxacin eye drops may be evaluated for their clinical usefulness in case of keratitis caused by Gram-negative bacilli.
铜绿假单胞菌性角膜炎难以治疗，而目前用于此目的的氨基糖苷类药物并不总是有效。因此，需要新药来治愈对庆大霉素耐药的铜绿假单胞菌眼部感染。依诺沙星是一种新型喹诺酮类药物，在体外对铜绿假单胞菌有活性，我们对其在由对庆大霉素耐药的铜绿假单胞菌分离株引起的兔实验性溃疡性角膜炎中进行了评估。我们的研究表明，依诺沙星滴眼液消除了角膜的铜绿假单胞菌感染，并在房水中达到了治疗浓度。静脉注射依诺沙星可增强这种效果。依诺沙星不能穿透玻璃体。对于革兰氏阴性杆菌引起的角膜炎，可评估依诺沙星滴眼液的临床实用性。
