Sugar A, Cohen M A, Bien P A, Griffin T J, Heifetz C L, Mehta S
Arch Ophthalmol. 1986 Aug;104(8):1230-2. doi: 10.1001/archopht.1986.01050200136068.
Enoxacin is a broad-spectrum quinolone-derivative antibiotic. In a rabbit model of keratitis caused by a Pseudomonas species, enoxacin (3 mg/mL) was as effective as gentamicin sulfate (3 mg/mL) and enoxacin (10 mg/mL) in reducing viable bacterial counts in corneas after 24 hours of hourly therapy with eye drops. Bacterial counts were reduced by about 5000-fold by enoxacin treatment when compared with placebo-treated controls. Penetration studies of topical enoxacin (3 mg/mL) showed that concentrations in cornea and aqueous humor reached levels above reported minimal inhibitory concentrations when an epithelial defect was present. Further investigation of enoxacin for treatment of ocular disease is warranted.
依诺沙星是一种广谱喹诺酮类衍生抗生素。在由假单胞菌属引起的角膜炎兔模型中，在用滴眼液每小时治疗24小时后，依诺沙星（3毫克/毫升）在降低角膜中活菌数方面与硫酸庆大霉素（3毫克/毫升）和依诺沙星（10毫克/毫升）效果相当。与安慰剂治疗的对照组相比，依诺沙星治疗使细菌数量减少了约5000倍。局部应用依诺沙星（3毫克/毫升）的渗透研究表明，当存在上皮缺损时，角膜和房水中的浓度达到高于报道的最低抑菌浓度的水平。因此有必要对依诺沙星治疗眼部疾病进行进一步研究。
