一例伴有MPLW515L/JAK2V617F共突变的慢性骨髓增殖性疾病患者中的双克隆扩增及异质性谱系受累情况 - Suppr

Biclonal expansion and heterogeneous lineage involvement in a case of chronic myeloproliferative disease with concurrent MPLW515L/JAK2V617F mutation.

作者信息

Hussein Kais, Bock Oliver, Theophile Katharina, Schlue Jerome, Ballmaier Matthias, Kröger Nicolaus, Göhring Gudrun, Büsche Guntram, Kreipe Hans

出版信息

Blood. 2009 Feb 5;113(6):1391-2. doi: 10.1182/blood-2008-01-136499.

DOI:10.1182/blood-2008-01-136499

PMID:19196872

Abstract

摘要

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Biclonal expansion and heterogeneous lineage involvement in a case of chronic myeloproliferative disease with concurrent MPLW515L/JAK2V617F mutation.一例伴有MPLW515L/JAK2V617F共突变的慢性骨髓增殖性疾病患者中的双克隆扩增及异质性谱系受累情况

Blood. 2009 Feb 5;113(6):1391-2. doi: 10.1182/blood-2008-01-136499.

Different lineage involvement in myelodysplastic/myeloproliferative disease with combined MPLW515L and JAK2V617F mutation.伴有MPLW515L和JAK2V617F联合突变的骨髓增生异常/骨髓增殖性疾病中不同谱系受累情况

Br J Haematol. 2009 Jun;145(5):673-5. doi: 10.1111/j.1365-2141.2009.07671.x. Epub 2009 Mar 31.

MPL mutation effect on JAK2 46/1 haplotype frequency in JAK2V617F-negative myeloproliferative neoplasms.MPL突变对JAK2V617F阴性骨髓增殖性肿瘤中JAK2 46/1单倍型频率的影响。

Leukemia. 2010 Apr;24(4):859-60. doi: 10.1038/leu.2010.1. Epub 2010 Jan 28.

[Expression of JAK2V617F and MPLW515L/K mutation in 30 suspected cases of early myeloproliferative disorders].[30例早期骨髓增殖性疾病疑似病例中JAK2V617F和MPLW515L/K突变的表达情况]

Zhonghua Xue Ye Xue Za Zhi. 2008 Sep;29(9):611-4.

[MPLW515L point mutation in patients with myeloproliferative disease].骨髓增殖性疾病患者中的MPLW515L点突变

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Dec;16(6):1421-4.

TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations.TG101209，一种小分子JAK2选择性激酶抑制剂，能有效抑制与骨髓增殖性疾病相关的JAK2V617F和MPLW515L/K突变。

Leukemia. 2007 Aug;21(8):1658-68. doi: 10.1038/sj.leu.2404750. Epub 2007 May 31.

Chronic myeloproliferative diseases with concurrent BCR-ABL junction and JAK2V617F mutation.伴有BCR-ABL融合及JAK2V617F突变的慢性骨髓增殖性疾病

Leukemia. 2008 May;22(5):1059-62. doi: 10.1038/sj.leu.2404993. Epub 2007 Nov 1.

Concurrent MPL515 and JAK2V617F mutations in myelofibrosis: chronology of clonal emergence and changes in mutant allele burden over time.骨髓纤维化中MPL515和JAK2V617F突变并存：克隆出现的时间顺序及突变等位基因负担随时间的变化

Br J Haematol. 2006 Dec;135(5):683-7. doi: 10.1111/j.1365-2141.2006.06348.x.

MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients.骨髓增殖性疾病及其他髓系疾病中的MPL515突变：1182例患者的研究

Blood. 2006 Nov 15;108(10):3472-6. doi: 10.1182/blood-2006-04-018879. Epub 2006 Jul 25.

TG101348, a JAK2-selective antagonist, inhibits primary hematopoietic cells derived from myeloproliferative disorder patients with JAK2V617F, MPLW515K or JAK2 exon 12 mutations as well as mutation negative patients.TG101348是一种JAK2选择性拮抗剂，可抑制源自患有JAK2V617F、MPLW515K或JAK2外显子12突变的骨髓增殖性疾病患者以及无突变患者的原代造血细胞。

Leukemia. 2008 Sep;22(9):1790-2. doi: 10.1038/leu.2008.56. Epub 2008 Mar 20.

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Biclonal expansion and heterogeneous lineage involvement in a case of chronic myeloproliferative disease with concurrent MPLW515L/JAK2V617F mutation.

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