Kocherga V I
Ukr Biokhim Zh. 1976 Sep-Oct;48(5):656-67.
The main role in determination of the pharmacologic effects of the imipramine groups antidepressants is given to their influence on neurotransmitters metabolism in synapses, the activity of enzymic systems regulating the transport of ions, as well as on the system of cyclic AMP metabolism. Interaction of tricyclic antidepressants with membrane and, as the result, distrubance in reuptake of transmitters (epinephrine and 5-hydroxytryptamine) in neurons is supposed to be one of the mechanisms of synaptic transmission regulation. The possible role in inhibition of biological amines deamination, in particular of phenylethylamine, in antidepressive effect of tricyclic antidepressants is discussed. It is supposed that the thymoanaleptic effects of the imipramine group antidepressants are due to activation of central serotoninergic processes, and their psychoanaleptic effect due to activation of the adrenergic system. Inhibition of the Na+, K+-ATPase activity quilizing effect of tricyclic antidepressants.
丙咪嗪类抗抑郁药药理作用的确定主要归因于它们对突触中神经递质代谢、调节离子转运的酶系统活性以及环磷酸腺苷代谢系统的影响。三环类抗抑郁药与细胞膜的相互作用以及由此导致的神经元中递质（肾上腺素和5-羟色胺）再摄取的紊乱被认为是突触传递调节的机制之一。文中讨论了三环类抗抑郁药在抑制生物胺脱氨基作用，特别是苯乙胺脱氨基作用方面在其抗抑郁作用中可能发挥的作用。据推测，丙咪嗪类抗抑郁药的情绪安定作用归因于中枢5-羟色胺能过程的激活，而其精神安定作用则归因于肾上腺素能系统的激活。三环类抗抑郁药的奎尼丁样作用可抑制钠、钾-ATP酶活性。
