米安色林对大鼠脑内单胺代谢的某些影响。
Some effects of mianserin on monoamine metabolism in the rat brain.
作者信息
Leonard B E
出版信息
Br J Clin Pharmacol. 1978;5 Suppl 1(Suppl 1):11S-12S.
Abstract
1 Mianserin does not affect the uptake of biogenic amines into rat brain, in contrast to tricyclic antidepressants which block amine uptake. 2 Mianserin increases the turnover of noradrenaline (NA) in rat brain after acute or chronic administration, whereas tricyclic antidepressants reduce turnover of NA and 5-hydroxytryptamine. 3 It should not be assumed that a compound must inhibit amine re-uptake mechanisms before it can be considered as a potential antidepressant.
摘要
- 与阻断胺摄取的三环类抗抑郁药不同，米安色林不影响生物胺进入大鼠脑内。2. 急性或慢性给予米安色林后，可增加大鼠脑内去甲肾上腺素（NA）的周转率，而三环类抗抑郁药则降低NA和5-羟色胺的周转率。3. 不应认为一种化合物在被视为潜在抗抑郁药之前必须抑制胺再摄取机制。
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