Zholdakova Z I, Sinitsyna O O, Kharchevnikova N V
Gig Sanit. 2008 Nov-Dec(6):12-6.
The properties of nanoparticles versus chemical compounds in other physical forms were evaluated in the context of classical toxicology. A relationship of the toxicity of nanomaterials to the structure of molecules and the size of nanoparticles is discussed. Summing up the data available in the literature leads to the conclusion that there are general and specific aspects in the study of the toxicity of nanoparticles and chemical substances in other physical forms. There is a relationship of their toxicity to the dose and time of exposure for both nanoparticles and other chemical substances. It is noted that, as in classical toxicology, main conclusions on the toxicity and hazard of nanoparticles can be drawn only from traditional chronic toxicological experiments on the adequate route of their entry into the body.
在经典毒理学的背景下，对纳米颗粒与其他物理形态的化合物的性质进行了评估。讨论了纳米材料毒性与分子结构及纳米颗粒大小之间的关系。总结文献中的现有数据得出结论，在研究纳米颗粒和其他物理形态化学物质的毒性方面存在一般和特定的方面。纳米颗粒和其他化学物质的毒性与其接触剂量和时间都有关系。需要指出的是，如同在经典毒理学中一样，关于纳米颗粒毒性和危害的主要结论只能从其进入体内的适当途径的传统慢性毒理学实验中得出。
