An Guk-Hwan, Kim Min-Jung, Lee Hak-Jong, Park Sang-Soo, Cho Yong Woo, Park Kinam, Choa Yong-Ho
Department of Fine Chemical Engineering, Hanyang University, 426-791 Gyeonggi-do, Korea.
J Nanosci Nanotechnol. 2008 Oct;8(10):5139-42. doi: 10.1166/jnn.2008.1138.
Terazocin should be frequently administered for a long period time for the treatment of benign prostatic hyperplasia which is one of the most common diseases in elderly men. Controlled delivery of terazocin using polymer microspheres has a great potential to solve the problem. In this study, terazocin-incorporated poly(D,L-lactide) (PDLLA) microspheres were fabricated by a novel ultrasonic spray drying (USD) method, which is a rapid one-step process. The approximate diameters of microspheres were in a range of between 0.3 and 3 microm. SEM confirmed that the microspheres had a spherical shape and narrow size distribution. FT-IR spectroscopy demonstrated that the incorporated terazocin remained intact after the USD process. The microspheres showed a fast initial burst release of terazocin within nine hours, followed by a slow but steady release for 49 days, suggesting that these microspheres are highly promising for controlled drug delivery.
对于治疗老年男性最常见疾病之一的良性前列腺增生，应长期频繁服用特拉唑嗪。使用聚合物微球控制特拉唑嗪的释放具有解决该问题的巨大潜力。在本研究中，通过一种新型超声喷雾干燥（USD）方法制备了载有特拉唑嗪的聚（D，L-丙交酯）（PDLLA）微球，这是一个快速的一步法过程。微球的近似直径在0.3至3微米范围内。扫描电子显微镜（SEM）证实微球呈球形且尺寸分布狭窄。傅里叶变换红外光谱（FT-IR）表明，载有的特拉唑嗪在超声喷雾干燥过程后保持完整。微球在9小时内显示出特拉唑嗪的快速初始突释，随后在49天内缓慢但稳定地释放，表明这些微球在药物控释方面具有很高的前景。
