Zou Tao, Li Song-Lin, Cheng Si-Xue, Zhang Xian-Zheng, Zhuo Ren-Xi
Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, People's Republic of China.
J Biomed Mater Res A. 2007 Dec 1;83(3):696-702. doi: 10.1002/jbm.a.31303.
Cholic acid functionalized star oligo/poly(DL-lactide)s with different molecular weights were synthesized through the ring-opening polymerization of DL-lactide initiated by cholic acid. On the basis of the specific physicochemical properties of the star oligo/poly(DL-lactide)s, submicron sized drug-delivery systems were fabricated using a very convenient "ultrasonic dispersion method," which did not involve toxic organic solvents. The drug-loaded microspheres had a regular spherical shape with a narrow size distribution. The effects of ultrasonic power and the molecular weight of polymers on the microsphere fabrication were investigated. The in vitro drug release was studied. The release profiles were fitted by the classical empirical exponential expression. The fitting result indicated that the drug release was controlled by combined degradation and diffusion mechanism.
通过胆酸引发DL-丙交酯的开环聚合反应，合成了具有不同分子量的胆酸功能化星型低聚/聚（DL-丙交酯）。基于星型低聚/聚（DL-丙交酯）的特定物理化学性质，采用非常简便的“超声分散法”制备了亚微米级药物递送系统，该方法不涉及有毒有机溶剂。载药微球呈规则球形，粒径分布窄。研究了超声功率和聚合物分子量对微球制备的影响。对体外药物释放进行了研究。释放曲线采用经典经验指数表达式拟合。拟合结果表明，药物释放受降解和扩散联合机制控制。
