Patel Amit R, Klein Eric A
Glickman Urological and Kidney Institute, The Cleveland Clinic, Cleveland, OH 44195, USA.
Nat Clin Pract Urol. 2009 Feb;6(2):87-95. doi: 10.1038/ncpuro1290.
The incidence of prostate cancer continues to increase in the US. Compared with other common cancers such as those of the breast and lung, the causes of prostate cancer remain poorly understood. Research endeavors continue to identify predictors of risk for prostate cancer, of which familial and genetic factors are among the strongest. Known risk factors can show significant heterogeneity in their association with prostate cancer development. However, the identification and further characterization of risk modifiers might provide insight into treatment and prevention of prostate cancer.
在美国,前列腺癌的发病率持续上升。与乳腺癌和肺癌等其他常见癌症相比,前列腺癌的病因仍知之甚少。研究工作仍在继续寻找前列腺癌的风险预测因素,其中家族因素和遗传因素是最主要的因素。已知的风险因素在与前列腺癌发展的关联中可能表现出显著的异质性。然而,识别风险调节因素并对其进行进一步的特征描述可能有助于深入了解前列腺癌的治疗和预防。