Bein Berthold, Fudickar Axel, Scholz Jens
Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
Anasthesiol Intensivmed Notfallmed Schmerzther. 2009 Feb;44(2):126-32; quiz 133. doi: 10.1055/s-0029-1202645. Epub 2009 Feb 6.
In vascular surgery, intraoperative monitoring of the brain is recommended when the internal carotid artery (ICA) is clamped, because brain damage by ischemia and embolism is possible. Clamping of the ICA results in embolic or ischemic brain lesions in about 7 % of all patients undergoing the procedure. Prophylactic routine insertion of an intraluminal shunt can cause brain embolism and does not reduce the occurrence of complications. Consequently, a shunt should only be inserted, if critical reduction of cerebral perfusion is evident after clamping the ICA. Measurement of carotid stump pressure is an invasive method to estimate perfusion of the brain hemisphere at the clamping side. Transcranial doppler sonography (TCD) measures the mean blood flow velocity in the ACI, but practicability is suffering from technical problems in 20% of all patients. However, TCD is useful for detecting intraoperative embolism and postoperative hyperperfusion. Changes of oxyhaemoglobine and desoxyhaemoglobine concentration in brain tissue can be measured using near-infrared spectroscopy (NIRS) with wavelengths between 700 and 1000 nm. NIRS measurement is easily performed and reacts quickly to changes of brain tissue oxygenation, but there is still lacking evidence and at present a general recommendation of its application in vascular surgery is not justified. Use of somatosensory evoked potentials (SEP) is the most widespread cerebral neuromonitoring during vascular surgery due to its high reliability and simple application. Sensitivity and specifity for ischemic lesions are 100% and 94%-99%, respectively. SEP are regarded as the gold standard for cerebral neuromonitoring in anaesthetized patients.
在血管外科手术中,当夹闭颈内动脉(ICA)时,建议进行术中脑监测,因为存在因缺血和栓塞导致脑损伤的可能性。在所有接受该手术的患者中,约7%会因夹闭ICA而导致栓塞性或缺血性脑损伤。预防性常规置入腔内分流管可导致脑栓塞,且不能减少并发症的发生。因此,只有在夹闭ICA后明显出现脑灌注显著降低时,才应置入分流管。测量颈动脉残端压力是一种评估夹闭侧脑半球灌注的有创方法。经颅多普勒超声(TCD)可测量大脑中动脉(MCA)的平均血流速度,但在所有患者中有20%会因技术问题而影响其实用性。然而,TCD对于检测术中栓塞和术后高灌注很有用。使用波长在700至1000纳米之间的近红外光谱(NIRS)可测量脑组织中氧合血红蛋白和脱氧血红蛋白浓度的变化。NIRS测量操作简便,对脑组织氧合变化反应迅速,但仍缺乏证据,目前在血管外科手术中普遍推荐使用该方法并不合理。体感诱发电位(SEP)因其高可靠性和应用简便,是血管外科手术中应用最广泛的脑神经监测方法。对缺血性损伤的敏感性和特异性分别为100%和94%-99%。SEP被视为麻醉患者脑神经监测的金标准。