Thansandote Praew, Gouliaras Christina, Turcotte-Savard Marc-Olivier, Lautens Mark
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Canada M5S3H6.
J Org Chem. 2009 Feb 20;74(4):1791-3. doi: 10.1021/jo8025725.
A palladium-catalyzed domino ortho-alkylation/alkenylation forming up to three new C-C bonds furnishes functionalized tetrahydroisoquinolines in up to 87% yield. Extension to the formation of tetrahydrobenzoazepines and tetrahydroisoquinolinones is presented.
一种钯催化的多米诺邻位烷基化/烯基化反应，可形成多达三个新的碳-碳键，以高达87%的产率提供功能化的四氢异喹啉。文中还介绍了该反应扩展用于形成四氢苯并氮杂䓬和四氢异喹啉酮的情况。
