Park Dong-Hyuk, Eve David J, Musso James, Klasko Stephen K, Cruz Eduardo, Borlongan Cesario V, Sanberg Paul R
Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, and College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA.
Stem Cells Dev. 2009 Jun;18(5):693-702. doi: 10.1089/scd.2009.0008.
Current treatments of neurological disorders such as Parkinson's disease and stroke are only partially effective. Consequently new therapies such as cell transplantation are of great interest. Cell therapy has shown promising results in animal models and in limited clinical trials. This form of treatment does have its own concerns, such as what factors control the survival and/or migration of the transplanted cells and how do they exert their benefit. Recent studies on tracking the transplants, such as prelabeling of the cells prior to transplant, and those elucidating the role of chemokines, as well as microglial and inflammatory responses, that may initiate the movement and survival of these cells are discussed in this review. A better understanding of these mechanism-driven pathways of neural repair will facilitate the clinical application of cell therapy for neurological disorders.
目前对帕金森病和中风等神经疾病的治疗仅部分有效。因此，细胞移植等新疗法备受关注。细胞疗法在动物模型和有限的临床试验中已显示出有前景的结果。这种治疗形式确实有其自身的问题，例如哪些因素控制移植细胞的存活和/或迁移，以及它们如何发挥益处。本文综述了近期关于追踪移植的研究，如移植前对细胞进行预标记，以及那些阐明趋化因子、小胶质细胞和炎症反应的作用的研究，这些因素可能启动这些细胞的移动和存活。更好地理解这些由机制驱动的神经修复途径将促进细胞疗法在神经疾病临床中的应用。
