Bye Nicole, Turnley Ann M, Morganti-Kossmann M Cristina
National Trauma Research Institute, Alfred Hospital, Department of Surgery, Monash University, Melbourne, Vic, Australia.
Neurosignals. 2012;20(3):132-46. doi: 10.1159/000336542. Epub 2012 Mar 28.
Brain injury following stroke or trauma induces the migration of neuroblasts derived from subventricular zone neural precursor cells (NPCs) towards the damaged tissue, where they then have the potential to contribute to repair. Enhancing the recruitment of new cells thus presents an enticing prospect for the development of new therapeutic approaches to treat brain injury; to this end, an understanding of the factors regulating this process is required. During the neuroinflammatory response to ischemic and traumatic brain injuries, a plethora of pro- and anti-inflammatory cytokines, chemokines and growth factors are released in the damaged tissue, and recent work indicates that a variety of these are able to influence injury-induced migration. In this review, we will discuss the contribution of specific chemokines and growth factors towards stimulating NPC migration in the injured brain.
中风或创伤后的脑损伤会诱导源自脑室下区神经前体细胞（NPCs）的神经母细胞向受损组织迁移，在那里它们有可能促进修复。因此，增强新细胞的募集为开发治疗脑损伤的新治疗方法带来了诱人的前景；为此，需要了解调节这一过程的因素。在对缺血性和创伤性脑损伤的神经炎症反应过程中，受损组织中会释放大量促炎和抗炎细胞因子、趋化因子和生长因子，最近的研究表明，其中多种因子能够影响损伤诱导的迁移。在这篇综述中，我们将讨论特定趋化因子和生长因子对刺激受损大脑中NPC迁移的作用。
