The perils of Alzheimer's drug development.
作者信息
Schneider Lon S, Lahiri Debomoy K
机构信息
Departments of Psychiatry, Neurology, and Gerontology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA.
出版信息
Curr Alzheimer Res. 2009 Feb;6(1):77-8. doi: 10.2174/156720509787313871.
Abstract
摘要
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Alzheimer's disease drug development in 2008 and beyond: problems and opportunities.2008年及以后的阿尔茨海默病药物研发：问题与机遇
Curr Alzheimer Res. 2008 Aug;5(4):346-57. doi: 10.2174/156720508785132299.
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Prevention therapeutics of dementia.痴呆症的预防疗法
Alzheimers Dement. 2008 Jan;4(1 Suppl 1):S122-30. doi: 10.1016/j.jalz.2007.11.005. Epub 2007 Dec 21.
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Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease.苯丝氨酸治疗对阿尔茨海默病脑功能活动及淀粉样蛋白的影响。
Ann Neurol. 2008 May;63(5):621-31. doi: 10.1002/ana.21345.
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Metrifonate for Alzheimer's disease.敌百虫用于治疗阿尔茨海默病。
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Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease.罗格列酮在基因明确的轻至中度阿尔茨海默病患者群体中的疗效。
Pharmacogenomics J. 2006 Jul-Aug;6(4):246-54. doi: 10.1038/sj.tpj.6500369. Epub 2006 Jan 31.
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Barriers to Alzheimer disease drug discovery and development in the biotechnology industry.
Alzheimer Dis Assoc Disord. 2002;16 Suppl 1:S29-32. doi: 10.1097/00002093-200200001-00005.
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Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease.他克林治疗的结果取决于阿尔茨海默病患者的载脂蛋白基因型和性别。
Neurology. 1998 Mar;50(3):669-77. doi: 10.1212/wnl.50.3.669.
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Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease.载脂蛋白E4等位基因作为阿尔茨海默病胆碱能缺陷和治疗结果的预测指标。
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