Rapposelli Simona, Digiacomo Maria, Balsamo Aldo
Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Università di Pisa, Via Bonanno 6, I-56126 Pisa, Italy.
Curr Top Med Chem. 2009;9(2):209-17. doi: 10.2174/156802609787521544.
This paper describes an overview of recent insights concerning some socially relevant neurodegenerative diseases such as Alzheimer's (AD), Parkinson's (PD), Huntington's (HD) and Creutzfeldt-Jakob's (CJD) diseases, amyotrophic lateral sclerosis (ALS) and epilepsy. For each pathological state, the direct and/or indirect involvement of P-glycoprotein (P-gp) efflux transport is underlined. On this basis, P-gp still represents an innovative target which can offer new tools for the development of more effective and preventive therapeutic strategies for neurodegenerative disorders. For each of them, therefore, a possible use of drugs affecting P-gp transport activity has been suggested.
本文概述了近期有关一些具有社会相关性的神经退行性疾病的见解，如阿尔茨海默病（AD）、帕金森病（PD）、亨廷顿病（HD）、克雅氏病（CJD）、肌萎缩侧索硬化症（ALS）和癫痫。对于每种病理状态，都强调了P-糖蛋白（P-gp）外排转运的直接和/或间接参与。在此基础上，P-gp仍然是一个创新靶点，可为神经退行性疾病开发更有效和预防性治疗策略提供新工具。因此，针对每种疾病，都有人提出了可能使用影响P-gp转运活性的药物。
