Wang Yi, Lv Meng-Nan, Zhao Wei-Jiang
Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, PR China.
Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, PR China; Department of Cell Biology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, PR China.
Ageing Res Rev. 2023 Nov;91:102035. doi: 10.1016/j.arr.2023.102035. Epub 2023 Aug 22.
Ferroptosis is an iron- and lipid peroxidation (LPO)-mediated programmed cell death type. Recently, mounting evidence has indicated the involvement of ferroptosis in neurodegenerative diseases, especially in Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and so on. Treating ferroptosis presents opportunities as well as challenges for neurodegenerative diseases. This review provides a comprehensive overview of typical features of ferroptosis and the underlying mechanisms that contribute to its occurrence, as well as their implications in the pathogenesis and advancement of major neurodegenerative disorders. Meanwhile, we summarize the utilization of ferroptosis inhibition in both experimental and clinical approaches for the treatment of major neurodegenerative disorders. In addition, we specifically summarize recent advances in developing therapeutic means targeting ferroptosis in these diseases, which may guide future approaches for the effective management of these devastating medical conditions.
铁死亡是一种由铁和脂质过氧化（LPO）介导的程序性细胞死亡类型。最近，越来越多的证据表明铁死亡参与神经退行性疾病，尤其是阿尔茨海默病（AD）、帕金森病（PD）、多发性硬化症（MS）、肌萎缩侧索硬化症（ALS）、亨廷顿病（HD）等。治疗铁死亡对神经退行性疾病来说既是机遇也是挑战。本综述全面概述了铁死亡的典型特征及其发生的潜在机制，以及它们在主要神经退行性疾病的发病机制和进展中的意义。同时，我们总结了铁死亡抑制在治疗主要神经退行性疾病的实验和临床方法中的应用。此外，我们特别总结了在开发针对这些疾病中铁死亡的治疗手段方面的最新进展，这可能为有效管理这些毁灭性疾病的未来方法提供指导。
