Wong Ee Tsin, Tergaonkar Vinay
Laboratory of NF-kappaB Signaling, Institute for Molecular and Cell Biology (A*STAR), 61, Proteos, 138673 Singapore.
Clin Sci (Lond). 2009 Mar;116(6):451-65. doi: 10.1042/CS20080502.
The NF-kappaB (nuclear factor kappaB) family of transcription factors are involved in a myriad of activities, including the regulation of immune responses, maturation of immune cells, development of secondary lymphoid organs and osteoclastogenesis. Fine tuning by positive and negative regulators keeps the NF-kappaB signalling pathway in check. Microbial products and genetic alterations in NF-kappaB and other signalling pathway components can lead to deregulation of NF-kappaB signalling in several human diseases, including cancers and chronic inflammatory disorders. NF-kappaB-pathway-specific therapies are being actively investigated, and these hold promises as interventions of NF-kappaB-related ailments.
转录因子核因子κB（NF-κB）家族参与众多活动，包括免疫反应调节、免疫细胞成熟、次级淋巴器官发育和破骨细胞生成。正负调节因子的精细调节使NF-κB信号通路受到控制。微生物产物以及NF-κB和其他信号通路成分的基因改变可导致多种人类疾病（包括癌症和慢性炎症性疾病）中NF-κB信号传导失调。目前正在积极研究NF-κB通路特异性疗法，这些疗法有望用于干预与NF-κB相关的疾病。
