Shiu Winnie Ka Po, Gibbons Simon
Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Phytochemistry. 2009 Feb;70(3):403-6. doi: 10.1016/j.phytochem.2008.12.016. Epub 2009 Feb 4.
In a project to isolate and characterise anti-staphylococcal compounds from members of the genus Hypericum, a dibenzofuran and a pyranone were isolated from the dichloromethane and hexane extracts of Hypericum revolutum ssp. revolutum Vahl (Guttiferae) and Hypericum choisianum Wall. ex. N. Robson (Guttiferae), respectively. The structures of these compounds were elucidated by 1- and 2D-NMR spectroscopy and mass spectrometry as 3-hydroxy-1,4,7-trimethoxydibenzofuran (1) and 4-(3-O-3'')-3''-methylbutenyl-6-phenyl-pyran-2-one (2). The metabolites were evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus. Compound 1 exhibited a minimum inhibitory concentration (MIC) of 256 microg/ml, whereas compound 2 was inactive at a concentration of 512 microg/ml.
在一项从金丝桃属植物中分离和鉴定抗葡萄球菌化合物的项目中，分别从赶山鞭亚种赶山鞭（金丝桃科）和匙萼金丝桃（金丝桃科）的二氯甲烷和己烷提取物中分离出一种二苯并呋喃和一种吡喃酮。通过一维和二维核磁共振光谱以及质谱分析确定这些化合物的结构分别为3-羟基-1,4,7-三甲氧基二苯并呋喃（1）和4-(3-O-3'')-3''-甲基丁烯基-6-苯基-吡喃-2-酮（2）。对一组耐多药金黄色葡萄球菌菌株评估了这些代谢产物。化合物1的最低抑菌浓度（MIC）为256微克/毫升，而化合物2在浓度为512微克/毫升时无活性。
