Shiu Winnie Ka Po, Gibbons Simon
Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Phytochemistry. 2006 Dec;67(23):2568-72. doi: 10.1016/j.phytochem.2006.09.037. Epub 2006 Nov 7.
As part of an ongoing project to investigate the anti-staphylococcal properties of the Hypericum genus, an acylphloroglucinol, 1,5-dihydroxy-2-(2'-methylpropionyl)-3-methoxy-6-methylbenzene (1), was isolated from the dichloromethane extract of the aerial parts of H. beanii (Guttiferae), together with a minor related acylphloroglucinol 1,5-dihydroxy-2-(2'-methylbutanoyl)-3-methoxy-6-methylbenzene (2) as a mixture in a 5:2 ratio. The known compounds 1,7-dihydroxyxanthone (3), stigmasterol, catechin and shikimic acid were also isolated from this plant. The structures of the compounds were characterized by extensive 1- and 2D NMR spectroscopy and mass spectrometry. The minimum inhibitory concentration (MIC) values the acylphloroglucinol mixture and (3) against a panel of multidrug-resistant strains of Staphylococcus aureus ranged from 16-32 microg/ml to 128-256 microg/ml, respectively.
作为一项正在进行的研究金丝桃属植物抗葡萄球菌特性项目的一部分，从豆叶金丝桃（藤黄科）地上部分的二氯甲烷提取物中分离出一种酰基间苯三酚，即1,5 - 二羟基 - 2 - (2'-甲基丙酰基)-3 - 甲氧基 - 6 - 甲基苯（1），以及一种少量的相关酰基间苯三酚1,5 - 二羟基 - 2 - (2'-甲基丁酰基)-3 - 甲氧基 - 6 - 甲基苯（2），二者以5:2的比例混合。还从该植物中分离出了已知化合物1,7 - 二羟基呫吨酮（3）、豆甾醇、儿茶素和莽草酸。通过广泛的一维和二维核磁共振光谱以及质谱对这些化合物的结构进行了表征。酰基间苯三酚混合物和（3）对一组耐多药金黄色葡萄球菌菌株的最低抑菌浓度（MIC）值分别为16 - 32微克/毫升至128 - 256微克/毫升。
