生物活性聚合物54. 改性新霉素的药理特性。

Bioactive polymers 54. Pharmacological properties of modified neomycin.

作者信息

Dumitriu S, Popa M, Dumitriu M, Vancea P, Mungiu O C, Costin D, Dumitriu D

机构信息

Polytechnic Institute of Jassay, Department of Macromolecular Technology, Romania.

出版信息

J Biomater Appl. 1991 Jul;6(1):80-8. doi: 10.1177/088532829100600106.

DOI:10.1177/088532829100600106

PMID:1920071

Abstract

Modified neomycin prepared by the ionic coupling on xanthan with an activity of 380 UI/mg was characterized in regard to its in vitro and in vivo release rate and therapeutic action with artificial tear eluent. The dynamic system in vitro release showed that after 4 h, there appears a "zero-order" kinetic. Ophthalmic inserts were prepared from modified neomycin and they are used in treating bacterial conjunctivitis. Sterilization of the conjunctival sac is obtained 12 h after insert administration.

摘要

通过离子偶联在黄原胶上制备的活性为380 UI/mg的改性新霉素，就其在体外和体内的释放速率以及在人工泪液洗脱液中的治疗作用进行了表征。体外释放的动态系统表明，4小时后出现“零级”动力学。由改性新霉素制备了眼用插入剂，并将其用于治疗细菌性结膜炎。插入剂给药12小时后可实现结膜囊的杀菌。