生物活性聚合物68——新霉素-呋喃唑酮双组分体系从黄原胶水凝胶中的控释

Bioactive polymers 68--controlled release of neomycin-furazolidone bicomponent system from xanthan hydrogel.

作者信息

Dumitriu S, Popa M I, Dumitriu M, Dumitriu D, Tara A

机构信息

Polytechnic Institute of Jassy, Department of Macromolecular Chemistry, Romania.

出版信息

J Biomater Appl. 1993 Jan;7(3):265-76. doi: 10.1177/088532829300700305.

DOI:10.1177/088532829300700305

PMID:8455136

Abstract

The neomycin-furazolidone-xanthan complex has been synthesized. Neomycin is covalently linked to xanthan, while furazolidone is inserted in the hydrogel formed by the reaction between neomycin and xanthan. The content of neomycin and furazolidone depends on the drug rate in the reaction medium. Thus, a zero-order kinetics is obtained for the release of both neomycin and furazolidone in basic medium. The complex's antimicrobial activity is intensified.

摘要

新霉素-呋喃唑酮-黄原胶复合物已被合成。新霉素与黄原胶共价连接，而呋喃唑酮则嵌入新霉素与黄原胶反应形成的水凝胶中。新霉素和呋喃唑酮的含量取决于反应介质中的药物比例。因此，在碱性介质中，新霉素和呋喃唑酮的释放均呈现零级动力学。该复合物的抗菌活性增强。