Gelfand Maria V, Hong Shangyu, Gu Chenghua
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Trends Cell Biol. 2009 Mar;19(3):99-110. doi: 10.1016/j.tcb.2009.01.001. Epub 2009 Feb 4.
The nervous and vascular systems are both exquisitely branched and complicated systems and their proper development requires careful guidance of nerves and vessels. The recent realization that common ligand-receptor pairs are used in guiding the patterning of both systems has prompted the question of whether similar signaling pathways are used in both systems. This review highlights recent progress in our understanding of the similarities and differences in the intracellular signaling mechanisms downstream of semaphorins, ephrins and vascular endothelial growth factor in neurons and endothelial cells during neural and vascular development. We present evidence that similar intracellular signaling principles underlying cytoskeletal regulation are used to control neural and vascular guidance, although the specific molecules used in neurons and endothelial cells are often different.
神经和血管系统都是高度分支且复杂的系统，它们的正常发育需要神经和血管的精确引导。最近认识到，在引导这两个系统的模式形成中使用了共同的配体-受体对，这引发了一个问题，即这两个系统是否使用相似的信号通路。本综述重点介绍了我们在理解神经和血管发育过程中，神经元和内皮细胞中信号素、 Ephrin 以及血管内皮生长因子下游的细胞内信号传导机制的异同方面的最新进展。我们提供的证据表明，尽管神经元和内皮细胞中使用的具体分子通常不同，但用于控制神经和血管引导的细胞骨架调节的细胞内信号传导原理是相似的。
