Neufeld Gera, Kessler Ofra
Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, P.O. Box 9679, 1 Efron Street, Haifa, 31096, Israel.
Nat Rev Cancer. 2008 Aug;8(8):632-45. doi: 10.1038/nrc2404. Epub 2008 Jun 26.
The semaphorins and their receptors, the neuropilins and the plexins, were originally characterized as constituents of the complex regulatory system responsible for the guidance of axons during the development of the central nervous system. However, a growing body of evidence indicates that various semaphorins can either promote or inhibit tumour progression through the promotion or inhibition of processes such as tumour angiogenesis, tumour metastasis and tumour cell survival. This Review focuses on the emerging role of the semaphorins in cancer.
信号素及其受体（神经纤毛蛋白和丛状蛋白）最初被确定为负责中枢神经系统发育过程中轴突导向的复杂调节系统的组成部分。然而，越来越多的证据表明，各种信号素可以通过促进或抑制肿瘤血管生成、肿瘤转移和肿瘤细胞存活等过程来促进或抑制肿瘤进展。本综述重点关注信号素在癌症中的新作用。
