Hayashi Yasuhiko, Shima Hiroshi, Kita Daisuke, Kinoshita Masashi, Yoshida Yuya, Hasegawa Mitsuhiro, Hamada Jun-ichiro
Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University 13-1, Takara-machi, Kanazawa, 920-8641, Japan.
J Clin Neurosci. 2009 Apr;16(4):568-70. doi: 10.1016/j.jocn.2008.04.030. Epub 2009 Feb 5.
A 41-year-old man presented with exophthalmos and loss of visual acuity. Neuroradiological studies showed a large mass extending from the intraorbital region to the frontal lobe. In addition, it also involved the middle cranial and infratemporal fossae with accompanying skull destruction. The tumor was almost totally removed. The histological diagnosis was sebaceous carcinoma with pagetoid changes. Despite surgery and local irradiation, intracranial metastases were recognized one year later, and the patient underwent total tumor removal and whole-brain irradiation. Although multiple lung metastases were detected one year after the second operation, three years post-surgery he remains free of intracranial tumor recurrence. Sebaceous carcinoma of meibomian gland origin with pagetoid changes is a distinct, highly aggressive clinical entity. Early diagnosis and appropriate treatment are essential to improve the prognosis of patients with meibomian gland carcinoma with intracranial extension.
一名41岁男性出现眼球突出和视力丧失。神经放射学检查显示一个大肿块从眶内区域延伸至额叶。此外，它还累及中颅窝和颞下窝，并伴有颅骨破坏。肿瘤几乎被完全切除。组织学诊断为伴有派杰样改变的皮脂腺癌。尽管进行了手术和局部放疗，但一年后仍发现颅内转移，患者接受了肿瘤全切和全脑放疗。第二次手术后一年虽检测到多处肺转移，但术后三年他仍未出现颅内肿瘤复发。起源于睑板腺且伴有派杰样改变的皮脂腺癌是一种独特的、侵袭性很强的临床实体。早期诊断和恰当治疗对于改善伴有颅内侵犯的睑板腺癌患者的预后至关重要。
