Russell W G, Page D L, Hough A J, Rogers L W
Am J Clin Pathol. 1980 Apr;73(4):504-11. doi: 10.1093/ajcp/73.4.504.
The clinical and pathologic features of four sebaceous carcinomas primary located in the eyelids were studied in detail. The neoplasms occurred in four patients of ages 62 to 76 years, were often misdiagnosed at initial excision, and recurred in all four cases. Three of the four cases required orbital exenteration, and preauricular lymph node metastases developed in two. The tumors were characterized by variable histologic growth patterns and evidence of sebaceous differentiation. Pagetoid spread of the neoplastic cells in the overlying epithelium was found in all four cases. Recognition of the pagetoid growth pattern in biopsy material was essential in correctly diagnosing two of the four cases. It is one of the important features enabling sebaceous carcinoma to be distinguished from basal cell carcinomas showing sebaceous differentiation.
对4例原发于眼睑的皮脂腺癌的临床和病理特征进行了详细研究。这些肿瘤发生在4例年龄为62至76岁的患者中，初次切除时常被误诊，且4例均复发。4例中有3例需要行眶内容剜除术，2例出现耳前淋巴结转移。肿瘤具有多种组织学生长模式及皮脂腺分化的证据。所有4例均发现肿瘤细胞在上皮中呈派杰样播散。活检材料中派杰样生长模式的识别对于正确诊断4例中的2例至关重要。它是使皮脂腺癌能够与显示皮脂腺分化的基底细胞癌相鉴别的重要特征之一。
