Martínez Ana I, Dominguez Angela, Oviedo Manuel, Minguell Sofia, Jansa Josep M, Codina Gemma, Vazquez Julio A
Department of Health, Generalitat of Catalonia, Roc Boronat 81-95, 08005 Barcelona, Spain.
Vaccine. 2009 May 26;27(25-26):3496-8. doi: 10.1016/j.vaccine.2009.01.045. Epub 2009 Feb 5.
Reported cases of meningococcal disease between 1997 and 2008 were analyzed to determine the evolution after the introduction of a conjugated vaccine. In <6 years, the incidence rate of serogroup C fell from 7.6 to 0.6 per 100,000 persons/year in the periods before (1997-2000) and after (2001-2007) the introduction of the conjugate vaccine. In serogroup B, the reduction was from 15.4 to 11.1. In <20 years case-fatality-rate increased only in serogroup B (3% and 7.4%, p=0.026). Serosubtype P1.15 was the most frequent in serogroup B (31%), mainly associated with serotype 4 (80%), and in serogroup C subtype P1.5 (36%), with serosubtype 2a (86%). Exhaustive surveillance of circulating meningococcal strains is essential.
对1997年至2008年期间报告的脑膜炎球菌病病例进行分析，以确定引入结合疫苗后的演变情况。在6岁以下儿童中，C群的发病率在引入结合疫苗之前（1997 - 2000年）为每10万人/年7.6例，之后（2001 - 2007年）降至每10万人/年0.6例。在B群中，发病率从15.4降至11.1。在20岁以下人群中，病死率仅在B群有所上升（分别为3%和7.4%，p = 0.026）。B群中最常见的血清亚型是P1.15（31%），主要与4型（80%）相关；C群中最常见的血清亚型是P1.5（36%），与血清亚型2a（86%）相关。对循环中的脑膜炎球菌菌株进行全面监测至关重要。
