Commun Dis Intell. 1998 Oct 1;22(10):205-11. doi: 10.33321/cdi.1998.22.47.
The National Neisseria Network (NNN) has undertaken meningococcal isolate surveillance by means of a collaborative laboratory based initiative since 1994. The phenotype (serogroup, serotype and serosubtype) and antibiotic susceptibility of 343 isolates of Neisseria meningitidis from invasive cases of meningococcal disease were determined in 1997. Ninety six percent of the invasive isolates were serogroup B or C. Serogroup B strains predominated in all States and Territories and were isolated from sporadic cases of invasive disease. Phenotypes B:4:P1.4 and B:15:P1.7 were prominent. Serogroup C isolates were most often encountered in New South Wales, especially in adolescents and young adults, and in that State were nearly as numerous as serogroup B strains. C:2a:P1.5 was the most frequently encountered phenotype and C:2b:P1.2 strains were also distributed widely. A number of clusters of cases of serogroup C disease were noted, mainly with phenotype C:2a:P1.5. About three quarters of all isolates showed decreased susceptibility to the penicillin group of antibiotics (MIC 0.06 to 0.5 mg/L). Three isolates showed reduced susceptibility to rifampicin and one was chloramphenicol resistant.
自1994年以来，国家奈瑟菌网络（NNN）通过一项基于实验室合作的举措开展了脑膜炎球菌分离株监测。1997年确定了343株来自侵袭性脑膜炎球菌病病例的脑膜炎奈瑟菌分离株的表型（血清群、血清型和血清亚型）及抗生素敏感性。96%的侵袭性分离株为B群或C群。B群菌株在所有州和领地均占主导地位，且从侵袭性疾病的散发病例中分离得到。B:4:P1.4和B:15:P1.7表型较为突出。C群分离株在新南威尔士州最为常见，尤其是在青少年和年轻人中，在该州其数量几乎与B群菌株一样多。C:2a:P1.5是最常遇到的表型，C:2b:P1.2菌株也广泛分布。注意到一些C群疾病病例聚集，主要为C:2a:P1.5表型。所有分离株中约四分之三对青霉素类抗生素的敏感性降低（最低抑菌浓度为0.06至0.5 mg/L）。3株分离株对利福平敏感性降低，1株对氯霉素耐药。
