Wagner C, Eckardt K, Ihn W, Schumann G, Stengel C, Fleck W F, Tresselt D
Institut für Mikrobiologie und experimentelle Therapie, Jena, Germany.
J Basic Microbiol. 1991;31(3):223-40. doi: 10.1002/jobm.3620310311.
On the basis of literature data and our own experiments the "late" biosynthetic pathway to daunomycin has been interpreted from a new point of view considering both the in vivo biosynthesis and formation of shunt products. In contrast to existing hypotheses proposed by other authors we discuss a modified sequence leading to C-11 oxidation and, as a consequence, understand epsilon-rhodomycinone as a shunt product instead of a biosynthetic intermediate. In addition, a new hypothesis about the "early" steps of the ring formation from polyketides by a sequence of enzyme reactions has been proposed.
基于文献数据和我们自己的实验，从一个新的角度解释了柔红霉素的“晚期”生物合成途径，同时考虑了体内生物合成和旁路产物的形成。与其他作者提出的现有假设相反，我们讨论了导致C-11氧化的修改序列，因此，将ε-红霉酮理解为旁路产物而非生物合成中间体。此外，还提出了一个关于聚酮化合物通过一系列酶反应形成环的“早期”步骤的新假设。
