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2
Isolation and characterization of a gene from Streptomyces sp. strain C5 that confers the ability to convert daunomycin to doxorubicin on Streptomyces lividans TK24.从链霉菌属菌株C5中分离和鉴定一个基因，该基因赋予淡紫灰链霉菌TK24将柔红霉素转化为阿霉素的能力。
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J Bacteriol. 1996 Jun;178(11):3389-95. doi: 10.1128/jb.178.11.3389-3395.1996.

本文引用的文献

1
Isolation and characterization of a gene from Streptomyces sp. strain C5 that confers the ability to convert daunomycin to doxorubicin on Streptomyces lividans TK24.从链霉菌属菌株C5中分离和鉴定一个基因，该基因赋予淡紫灰链霉菌TK24将柔红霉素转化为阿霉素的能力。
J Bacteriol. 1996 Jun;178(11):3389-95. doi: 10.1128/jb.178.11.3389-3395.1996.
2
The unstable melC operon of Streptomyces antibioticus is codeleted with a Tn4811-homologous locus.抗生链霉菌不稳定的melC操纵子与一个Tn4811同源位点共缺失。
J Bacteriol. 1993 Mar;175(6):1847-52. doi: 10.1128/jb.175.6.1847-1852.1993.
3
Saccharopolyspora hirsuta 367 encodes clustered genes similar to ketoacyl synthase, ketoacyl reductase, acyl carrier protein, and biotin carboxyl carrier protein.多毛糖多孢菌367编码与酮酰基合成酶、酮酰基还原酶、酰基载体蛋白和生物素羧基载体蛋白相似的成簇基因。
Mol Gen Genet. 1993 Jul;240(1):146-50. doi: 10.1007/BF00276894.
4
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.链霉菌基因簇的克隆、测序及推导功能，该基因簇可能编码聚酮类抗生素弗罗利辛的生物合成。
Gene. 1994 May 3;142(1):31-9. doi: 10.1016/0378-1119(94)90351-4.
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Nucleotide sequence of the aknA region of the aklavinone biosynthetic gene cluster of Streptomyces galilaeus.加利利链霉菌阿克拉维酮生物合成基因簇的aknA区域的核苷酸序列。
J Bacteriol. 1994 Apr;176(8):2473-5. doi: 10.1128/jb.176.8.2473-2475.1994.
6
DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2).天蓝色链霉菌A3(2)放线紫红素生物合成基因簇actVI区域的DNA序列及功能
J Biol Chem. 1994 Oct 7;269(40):24854-63.
7
Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.来自产柔红霉素链霉菌菌株C5的聚酮合酶基因的分离与序列分析
J Bacteriol. 1994 Oct;176(20):6270-80. doi: 10.1128/jb.176.20.6270-6280.1994.
8
Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5.对链霉菌属菌株C5中编码柔红霉素生物合成早期和晚期步骤的成簇基因的分析。
J Bacteriol. 1995 Feb;177(3):536-43. doi: 10.1128/jb.177.3.536-543.1995.
9
Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase.编码柔红霉素聚酮合酶的佩西链霉菌ATCC 29050基因的表征
Gene. 1994 Dec 30;151(1-2):1-10. doi: 10.1016/0378-1119(94)90625-4.
10
Functional characterization and transcriptional analysis of a gene cluster governing early and late steps in daunorubicin biosynthesis in Streptomyces peucetius.产柔红霉素链霉菌中控制柔红霉素生物合成早期和晚期步骤的基因簇的功能表征及转录分析。
J Bacteriol. 1995 Jul;177(13):3879-84. doi: 10.1128/jb.177.13.3879-3884.1995.

链霉菌属菌株C5中阿克laviketone还原酶的克隆、测序及分析。

Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.

作者信息

Dickens M L, Ye J, Strohl W R

机构信息

Department of Microbiology, Ohio State University, Columbus, 43210, USA.

出版信息

J Bacteriol. 1996 Jun;178(11):3384-8. doi: 10.1128/jb.178.11.3384-3388.1996.

DOI:10.1128/jb.178.11.3384-3388.1996
PMID:8655529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC178101/
Abstract

DNA sequence analysis of a region of the Streptomyces sp. strain C5 daunomycin biosynthesis gene cluster, located just upstream of the daunomycin polyketide biosynthesis genes, revealed the presence of six complete genes. The two genes reading right to left include genes encoding the potentially translationally coupled gene products, an acyl carrier protein and a ketoreductase, and the four genes reading divergently, left to right, include two open reading frames of unknown function followed by a gene encoding an apparent glycosyltransferase and dauE, encoding aklaviketone reductase. Extracts of Streptomyces lividans TK24 containing recombinant DauE catalyzed the NADPH-specific conversion of aklaviketone, maggiemycin, and 7-oxodaunomycinone to aklavinone, epsilon-rhodomycinone, and daunomycinone, respectively. Neither the product of dauB nor that of the ketoreductase gene directly downstream of the acyl carrier protein gene demonstrated aklaviketone reductase activity.

摘要

对链霉菌属菌株C5柔红霉素生物合成基因簇中位于柔红霉素聚酮生物合成基因上游区域的一段DNA序列进行分析，发现存在六个完整基因。两个从右向左读码的基因包括编码可能翻译偶联的基因产物的基因，一个酰基载体蛋白和一个酮还原酶，而四个从左向右反向读码的基因包括两个功能未知的开放阅读框，接着是一个编码明显糖基转移酶的基因和dauE，dauE编码阿克拉酮还原酶。含有重组DauE的变铅青链霉菌TK24提取物催化阿克拉酮、马吉霉素和7-氧柔红霉素酮分别特异性地转化为阿克拉文酮、ε-红霉内酯酮和柔红霉素酮。酰基载体蛋白基因直接下游的dauB产物和酮还原酶基因产物均未表现出阿克拉酮还原酶活性。