Tsutsumi Ryo, Hiroi Hisahiko, Momoeda Mikio, Hosokawa Yumi, Nakazawa Fumiko, Yano Tetstu, Tsutsumi Osamu, Taketani Yuji
Department of Obstetrics and Gynecology, the University of Tokyo, Tokyo, Japan.
Fertil Steril. 2009 Apr;91(4 Suppl):1614-7. doi: 10.1016/j.fertnstert.2008.12.055. Epub 2009 Feb 6.
To investigate the effect of cadmium (Cd) contamination on endometrial function, human endometrial stromal cells were isolated and cultured with E(2) plus P in the presence of Cd, a major contaminant in cigarette smoke, and assayed for PRL concentrations and its messenger RNA expression. Cd significantly increased PRL concentrations in the culture media and significantly up-regulated PRL messenger RNA expression of the endometrial stromal cells, suggesting that Cd stimulates decidualization of the endometrium and may disrupt endometrial environment, causing early decidualization.
为研究镉（Cd）污染对子宫内膜功能的影响，分离人子宫内膜基质细胞，并在香烟烟雾中的主要污染物Cd存在的情况下，用雌二醇（E₂）加孕酮（P）进行培养，检测催乳素（PRL）浓度及其信使核糖核酸（mRNA）表达。Cd显著增加了培养基中的PRL浓度，并显著上调了子宫内膜基质细胞的PRL信使核糖核酸表达，表明Cd刺激子宫内膜蜕膜化，可能破坏子宫内膜环境，导致早期蜕膜化。
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